1. 指定域名不使用代理

import os
import requests

os.environ['NO_PROXY'] = 'stackoverflow.com'

response = requests.get('http://www.stackoverflow.com')

2. 设置代理为None

import requests

proxies = {
  "http": None,
  "https": None,
}

requests.get("http://example.org", proxies=proxies)  

3. 设置trust_env = False

import requests

session = requests.Session()
session.trust_env = False

response = session.get('http://www.stackoverflow.com')